1. What Is Urine Creatinine Clearance?

Creatinine clearance is a test that measures how effectively the kidneys are clearing creatinine from the blood. It provides an estimate of the glomerular filtration rate (GFR) and is used to assess kidney function.

2. How Does The Calculator Work?

The calculator uses the creatinine clearance formula:

Where:

• \( U_{cr} \) — Urine creatinine concentration (mg/dL)
• \( V \) — Urine volume per minute (mL/min)
• \( P_{cr} \) — Plasma creatinine concentration (mg/dL)

Explanation: This formula calculates the volume of plasma cleared of creatinine per minute by the kidneys, providing a direct measurement of renal clearance capacity.

3. Importance Of Creatinine Clearance Calculation

Details: Creatinine clearance is essential for evaluating kidney function, monitoring renal disease progression, adjusting medication dosages for renally excreted drugs, and assessing overall renal health.

4. Using The Calculator

Tips: Enter urine creatinine in mg/dL, urine volume in mL/min, and plasma creatinine in mg/dL. All values must be positive numbers greater than zero for accurate calculation.

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between creatinine clearance and eGFR?
A: Creatinine clearance is a measured value from urine and blood samples, while eGFR is an estimated value calculated from blood creatinine and demographic factors.

Q2: How should urine collection be performed for this test?
A: Typically, a 24-hour urine collection is used, with the total volume divided by 1440 to get mL/min. Blood sample should be drawn during the collection period.

Q3: What are normal creatinine clearance values?
A: Normal range is approximately 95-125 mL/min for men and 85-115 mL/min for women, but varies with age, body size, and muscle mass.

Q4: When is creatinine clearance preferred over eGFR?
A: In patients with extreme body habitus, amputees, pregnant women, or when precise drug dosing is critical for renally excreted medications.

Q5: What factors can affect creatinine clearance results?
A: Incomplete urine collection, meat consumption before testing, vigorous exercise, certain medications, and dehydration can all influence results.